Poster Presentations

Ozone Detection in Pharmaceutical Containers
Charlotte Bell1, Elaine Martin1, Brendan Fish2

1Biopharmaceutical and Bioprocessing Technology Centre, Newcastle University, UK
2GlaxoSmithKline, Barnard Castle, UK


An orthogonal approach to pre-formulation and stability studies
Michael S. Caves, Marisa C. Barnard, Inigo Rodriguez-Mendieta, Mark I. Millichip

The SGS M-Scan Centre of Excellence in Biophysical Analysis, SGS M-Scan Limited, 2-3 Millars Business Centre, Wokingham, Berkshire, RG41 2TZ


Challenges in the measurement of protein zeta potential
Jason CW Corbett, Mark R Pothecary, Paul Clarke, Michael Kaszuba, Ciaran Murphy

Malvern Instruments Ltd., Enigma Business Park, Malvern, Worcestershire, WR14 1XZ


An atomic force microscopy based method for biopharmaceutical stability determination
O. Croad1, D. J. Scott2, C. J. Roberts1, S. Rigby-Singleton3, P. M. Williams1, and S. Allen1

1Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, UK
2School of Biosciences, The University of Nottingham, LE12 5RD, UK;
3Molecular Profiles Ltd., 8 Orchard Place, Nottingham Business Park, NG8 6PX, UK


Biosensor and chromatography based strategies for high throughput measurement of protein self-association during formulation development
Krisztina Kovacs-Schreiner1, Olatomirin Kolade1, Brendan Fish2, Daniel G. Bracewell1

1Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, UCL, UK
2GlaxoSmithKline, Barnard Castle, UK


Protein Stabilisers: New Opportunities from Patent Expiry
Arthur P. Lallement

CambridgeIP Ltd, Cambridge, UK


The Development of a Systematic Coarse-Grain Model for Polymer Drug Encapsulation
Robbie Mackenzie1, Charles Laughton1, Martin Garnett1, Cameron Alexander1, Jonathan Booth2

1School of Pharmacy, University of Nottingham, UK
2AstraZeneca, Macclesfield, UK


Protein crystals as formulations for protein delivery
Nuno Madeira do Ó, Snow Stolnik

University of Nottingham, University Park, NG7 2RD, Nottingham


Use of Dynamic Mechanical Analysis and Dynamic Scanning Calorimetry in the Determination of Critical Temperature Parameters for the Stabilization of Freeze-dried Biologicals
Kiran Malik, Chinwe Duru & Paul Matejtschuk

National Institute for Biological Standards & Control (NIBSC) – A Centre of the Health Protection Agency, Blanche Lane , South Mimms, Potters Bar , Herts. EN6 3QG. United Kingdom.


Antibody analyses with Biacore™ system - convenient , sensitive, versatile
Ewa Pol, Anna Moberg and Robert Karlsson

GE Healthcare BioSciences AB, Uppsala, Sweden


Dry powder therapeutic mAb formulations with enhanced temperature stability
F. McNamee1, W. Gebbie1, K. Davidson1, J. Partridge1, J. Vos1, J. Abate2, C. Kirchhoff2, B. D. Moore1

1XstalBio Ltd, Thomson Building, University Avenue, Glasgow, G12 8QQ, U.K
2Pfizer Global Research & Development, 700 Chesterfield Parkway West, Chesterfield USA


Capillary Electrophoresis as a Powerful Tool in Therapeutic Protein Production Analytics
Mei-an Sung

deltaDOT Ltd, London BioScience Innovation Centre, 2 Royal College Street, London, NW1 0NH


Bio-functional Hydrolysates of Heat-denatured Whey Proteins
I.B. O'Loughlin1,2, B.A. Murray1, P.M. Kelly1, A.A. Robinson3, R.J. FitzGerald2, and A. Brodkorb1*
F. McNamee1, W. Gebbie1, K. Davidson1, J. Partridge1, J. Vos1, J. Abate2, C. Kirchhoff2, B. D. Moore1

1XstalBio Ltd, Thomson Building, University Avenue, Glasgow, G12 8QQ, U.K
2Pfizer Global Research & Development, 700 Chesterfield Parkway West, Chesterfield USA


Computational Pharmaceutics - How to Apply Molecular Modelling Techniques in Drug Delivery
Defang Ouyang

Aston Pharmacy School, School of Life & Health Sciences, Aston University, Birmingham, B4 7ET, UK


Investigation of the Pharmacokinetic Properties of Aspirin Analogues
B.Raj, C.J.Perry

School of Applied Sciences, University of Wolverhampton, Wolverhampton, UK.


Understanding and predicting aggregation in biopharmaceuticals
Dorota Roberts

Manchester Institute of Biotechnology, CEAS, the University of Manchester, Manchester, UK


Microscale freeze-dried and liquid formulations of biotherapeutics to investigate the relationship between forced degradation and long-term shelf life
Mathew Robinson1, Dr. Paul Dalby1, Dr. Paul Matejtschuk2, Dr. Adrian Bristow2, Dr Colin Longstaff2, Dr. Dan Bracewell1

1Department of Biochemical Engineering, University College London (UCL), London, UK
2National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK


Thermal characterization of protein based sterile ocular implants
Garima U. Sharma1, Kiran Malik2, Ashkan Khalili1, Teresa Barata3, Paul Matejtschuk2, Peng Khaw1, Steve Brocchini1

1UCL School of Pharmacy and NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, UK
2Standardization Science, National Institute for Biological Standards and Control, Health Protection Agency, Potters Bar, UK


The Evaluation of High Throughput Apparent Solubility and Conformation Assays as Predictive Tools for Early Stage Formulation Development
Harriet Crawley-Snowdon1*, Neil Mody2, Malgorzata Tracka1

1MedImmune Department of Formulation Sciences in Cambridge, UK
2MedImmune Department of Formulation Sciences in Gaithersburg, USA
*University of Kent


Inhalable formulations loaded with therapeutic protein constructs
F. van de Manakker1*, A.W. Weber1, K. Baumann2, and J. Ferré2

1FeyeCon Carbon Dioxide Technologies, Rijnkade 17A, 1382 GS, Weesp, The Netherlands
2Arquebio S.L., Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, S