Poster Abstracts 

 

Microfluidic production of drug-loaded biodegradable polymer microparticles for drug-delivery applications

Tymèle Deydier, Guido Bolognesi and Goran T. Vladisavljević
Loughborough University, Department of Chemical Engineering

Biodegradable polymeric microparticles find widespread use in controlled drug delivery. In this research, biodegradable polymer microparticles with tuneable size and surface morphology containing a hydrophobic drug were produced via oil-in-water emulsion in a glass 3D flow-focusing microfluidic chip with 100μm-deep channels. The oil phase was a polymer-drug solution in a volatile organic solvent (dichloromethane or dimethyl carbonate) and the aqueous phase was a polyvinyl alcohol (PVA) solution. After solvent evaporation, the droplets solidified into particles with highly uniform size ranging from 10 to 30 μm and a coefficient of variation of less than 3%. The solvent evaporation-induced phase separation between the polymer and the drug resulted in patchy particle morphologies at very high polymer to drug ratio (4:1) in the initial oil phase and in Janus morphologies for other polymer to drug ratios (2:1, 1:1, 1:4, and 1:9).

Acknowledgement:
This work was supported by Med Alliance LLC and ESPCR National Productivity Investment Fund.

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Surface Energy and Solubility Parameter Analysis of Soluplus® using Inverse Gas Chromatography
Nachal Subramanian, Majid Naderi, Daniel Burnett, Armando Garcia
Surface Measurement Systems Ltd., Unit 5 Wharfside, Alperton, London, UK

Soluplus®, a polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer (PEG/PVCp/PVAc), has been extensively studied as a polymeric solubilizer to enhance the solubility of poorly soluble drugs using the solid solution/dispersion approach. It has a low glass transition temperature (Tg), low hygroscopicity and high solubility in water and organic solvents, which offers advantages over cellulose based and/or PVP based excipients. Most techniques that are used to investigate the solubility/miscibility of polymers with drugs require a complete understanding of the chemical structure or composition of the polymer and the drug which often leads to inaccurate results. In contrast, iGC SEA technique provides accurate values of solubility parameters without requiring the polymer structure or composition. In this study, inverse gas chromatography Surface Energy Analyzer (iGC SEA) was used to examine the surface energy properties - dispersive and specific surface energies, and free energy of desorption for various polar solvents. In addition, solubility parameters of Soluplus® and the extrudate with carbamazepine as a model Class II drug were determined.